Making Sense of Biological Designs

We are curious about how biological systems are built. We want to understand the engineering principles and molecular mechanisms of how things are built and how things function. In the lab, we study multiple scales of biological organisation, from small protein circuits, signaling pathways, developmental programs, to organisms. We enjoy using various tools, such as paper-and-pencil mathematical modeling, computer simulation, biochemistry, single-cell imaging, histology, molecular biology, experiments in frog embryos, and lately, some cutting and grinding experiments in jellies.

Check out our Systems Biology Program at Caltech!



November 13, 2018

*drum roll*  Check out Harry’s paper that just came out in eLife!   The title of the paper is: Signaling pathways as linear transmitters.  Also check out an accompanying Insight article by Steven Andrews, Roger Brent, and Gabor Balazsi.  We are so proud of this paper, so much work went into it.  The peer-review process was tough, but it really made the paper better in the end.  So thank you to the editor and reviewers at eLife who kindly took their time to critique the paper!

April 20, 2018

Noah wrote an opinion piece for Current Opinion in Biotechnology, There is (still) plenty of room at the bottom.  Inspired by Feynman’s lecture 60 years ago, Noah argues that even as the field moves forward to analyze more and more complex networks comprised of many molecules, there are still many fascinating computations to be discovered within the molecules, and that understanding these computations may have interesting ramifications.

April 19, 2018

Welcome, Lev Tsypin!  Lev is rotating in the lab this quarter.  He is exploring several fun ideas for projects, some of which involve possibly expanding the organismal ecosystem in the lab.  Check out Lev posing with an old microscope from Seymour Benzer’s lab.

April 17, 2018

Lea is promoted to Professor of Biology.  Props to everyone, it is a recognition of our work together.

March 30, 2018

Congratulations, Noah!  Noah will join Johan Paulsson’s lab at the Department of Systems Biology, Harvard Medical School as a postdoc.  What great news!  But of course, he has to graduate first.

March 15, 2018

The lab has welcomed many young trainees over these years.  It is wonderful to hear their updates, and cherish their adventures.  Here are some updates we’ve received so far:  Beatriz Aleman graduated from high school and is now at UC Berkeley.  Isabella Boyle is at University of Chicago, and Ivan Schmidt will start there soon, too.  Paola Benefo will join David’s lab at UC Davis as a research technician.  William Yuan is now pursuing PhD in Biological Sciences at Harvard.  And Bryan Ryba is in his third year pursuing MD/PhD at UCSD.  We hope they are all having fun.