Signaling pathways as linear transmitters

Harry Nunns and Lea Goentoro
eLife, in press

The Jellyfish Cassiopea Exhibits a Sleep-like State

Ravi D. Nath*, Claire N. Bedbrook*, Michael J. Abrams*, Ty Basinger, Justin S. Bois, David A. Prober, Paul W. Sternberg, Viviana Gradinaru, Lea Goentoro†
Current Biology, doi:10.1038/nature.2017.22654

Press Release:

Caltech. The Surprising, Ancient Behavior of Jellyfish.  By Lori Dajose.

Two-Element Transcriptional Regulation in the Canonical Wnt Pathway.

Kibeom Kim, Jaehyoung Cho, Thomas S. Hilzinger, Harry Nunns, Andrew Liu, Bryan E. Ryba, Lea Goentoro
Current Biology, doi:10.1016/j.cub.2017.06.037

Sensing relative signal in the Tgf-β/Smad pathway

Christopher L. Frick*, Clare Yarka, Harry Nunns, and Lea Goentoro
PNAS 114 (14): E2975–E2982, 2017

Press release:
Caltech. Cells Calculate Ratios to Control Gene Expression.  By Lori Dajose.

F1000 Prime.  Recommended by Tamara Alliston, UCSF; and Bas Teusink, Vrije Universiteit Amsterdam


Cross-hierarchy systems principle

Lea Goentoro
Current Opinions in Systems Biology

An invited perspective for the inaugural issue of Current Opinion in Systems Biology. See a wonderful introduction by Arnold Levine to commence the issue The Future of Systems Biology.

Allosteric proteins as logarithmic sensors

Noah Olsman and Lea Goentoro
PNAS 113 (30): E4423-4430, 2016

See an invited blurb we wrote in Cell Systems. Principles of Systems Biology No. 8. How do cells compute logarithm?

Symmetrization in jellyfish: reorganization to regain function, and not lost parts

Michael Abrams and Lea Goentoro

An invited Perspective.

Self-repairing symmetry in jellyfish through mechanical reorganization

Michael Abrams, Ty Basinger, William Yuan, Chin-Lin Guo, and Lea Goentoro
PNAS, published online before print June 15, 2015

See some news on our work


Fold-change detection and scalar symmetry of sensory input fields

Oren Shoval, Lea Goentoro, Yuval Hart, Avi Mayo, Eduardo Sontag, and Uri Alon
PNAS 107 (36), 15995–16000, 2010

Evidence that fold change, not absolute level, of b-catenin dictates Wnt signalling

Lea Goentoro and Marc W. Kirschner
Molecular Cell 36 (5), 872-884, 2009

See commentaries on our work:
Signaling motifs and Weber’s Law,  James E. Ferrell,  Molecular Cell 36 (5), 724-727, 2009
It’s All Relative,  Nancy R. Gough, Science Signaling 2 (101), ec397, 2009
Signalling: Sensing a change, Tanita Casci, Nature Reviews Genetics 11, 92-93, 2010

The incoherent feedforward loop can provide fold-change detection in gene regulation

Lea Goentoro, Oren Shoval, Marc W. Kirschner, and Uri Alon
Molecular Cell 36 (5), 894-899, 2009

Quantifying the Gurken Morphogen Gradient in Drosophila Oogenesis

Lea Goentoro, Gregory T. Reeves, Craig P. Kowal, Luigi Martinelli, Trudi Schüpbach, and Stanislav Y. Shvartsman
Developmental Cell 11 (2), 263-272, 2006

Quantitative analysis of the GAL4/UAS system in Drosophila oogenesis

Lea Goentoro, Nir Yakoby, Joseph Goodhouse, Trudi Schüpbach, Stanislav Y. Shvartsman
Genesis 44 (2), 66-74, 2006