Relative perception in the Wnt pathway

Here is an idea we are very ardently pursuing in the lab. In multicellular animals, cells constantly signal with one another to coordinate function.  About twenty or so signaling pathways have been identified so far. Each signaling pathway consists of a network of dozens of interacting proteins. How do these pathways transduce signal from outside into specific responses inside the cells?  How is information propagated?  When we set out to ask these questions, we found that another question had to … Continue reading Relative perception in the Wnt pathway