Making Sense of Biological Designs

We are curious about how biological systems are built. We want to understand the engineering principles and molecular mechanisms of how things are built and how things function. In the lab, we study multiple scales of biological organisation, from small protein circuits, signaling pathways, developmental programs, to organisms. We enjoy using various tools, such as paper-and-pencil mathematical modeling, computer simulation, biochemistry, single-cell imaging, histology, molecular biology, experiments in frog embryos, and lately, some cutting and grinding experiments in jellies.

Check out our Systems Biology Program at Caltech!



July 13, 2016

And hooray!!!  Noah’s work just came out in PNAS.  Read the paper: Allosteric Proteins as Logarithmic Sensors.

June 13, 2016

And it’s summer time again.  We welcome Laura Ratliff, a rising senior from Flintridge Prep, returning to the lab this time to learn to clone and make movies of cells.  We also welcome a new technician in the lab, Andrew Liu, who graduated from Cal and joined the lab to tackle the b-catenin project with Kibeom.  We have great hopes for him.

January 5, 2016

Happy New Year!  Check out Noah’s new website at

December 15, 2015

We have an opening for a lab tech.  If you are a college graduate looking for more lab experience, consider applying to us.  Click here for project description.

August 25, 2015

We got interviewed again!  This time by the NPR Big Picture Science.  Click here to listen to Lea and Michael explaining symmetrization to Molly Bentley and Seth Shostak, a Caltech alumnus himself.

August 5, 2015

We are sad Clare is leaving.  She has been such a great presence in the lab.  But we are  happy that she’s going to an exciting Master program in Regenerative Stem Cells at USC.  Here is a toast to the bright future ahead!